Caffeine intake associated with a lower risk of liver fibrosis in different glucose status

作者：Jiahao Han, Chuan Liu, Huanhuan Yang, Zihe Dong, Xiaoguo Li, Ruixia Gao, Jie Li, Jie Li, Qun Zhang, Wai‐Kit Ming, Zhihui Li, Jia Li, Jia Li, Xiaolong Qi · 发表于：Journal of Advanced Research · 年份：2025 · DOI：10.1016/j.jare.2025.02.004 · 被引用次数：3 · 研究领域：Coffee research and impacts、Liver Disease Diagnosis and Treatment、Tea Polyphenols and Effects

BACKGROUND AND AIMS: To investigate the prevalence of liver fibrosis, and the association between caffeine intake and fibrosis in populations with different glucose metabolism status. METHODS: This was a cross-sectional study based on the National Health and Nutrition Examination Survey (2005-March 2020). Of the 39,221 adult individuals with no necessary laboratory results missing, a total of 23,711 eligible individuals were included in the study. Individuals were divided into T2DM, prediabetes, and diabetes-free groups. Fibrosis-4 index was calculated to evaluate the risk of liver fibrosis. Caffeine intake was obtained through a 24-hour dietary recall. RESULTS: The mean ± SE age of prediabetes group was 53 ± 0·4 years, and in type 2 diabetes mellitus group, the individuals have a mean ± SE age of 62 ± 0·3 years. The participants with type 2 diabetes mellitus had significantly higher risk of liver fibrosis than those with prediabetes or normal glucose tolerance (5·9% vs. 3·2% vs. 2·5%, P < 0·001). Compared to individuals with daily caffeine intake < 78 mg, individuals with daily caffeine intake ≥ 78 mg had significantly lower risk of liver fibrosis in all subgroups (odds ratio: diabetes-free group: 0·698[0·577-0·846]; prediabetes group: 0·553[0·397-0·769]; type 2 diabetes mellitus group: 0·720[0·556-0·933]; all P < 0·05). CONCLUSIONS: Prevalence of liver fibrosis is high in patients with type 2 diabetes mellitus and prediabetes. It is indicated that individuals with prediabet...