Tracing the evolution: the rise of Salmonella Thompson co-resistant to clinically important antibiotics in China, 1997–2020

作者：Weishuai Zhai, Mi Lu, Lanxin Zhao, Pengcheng Du, Shenghui Cui, Yang Liu, Dongmei Tan, Xianying Zeng, Baowei Yang, Ruichao Li, Séamus Fanning, Dejun Liu, L. Li, Xiaoman Zhang, Yang Wang, Li Bai · 发表于：mSystems · 年份：2025 · DOI：10.1128/msystems.01018-24 · 被引用次数：10 · 研究领域：Salmonella and Campylobacter epidemiology、Antibiotic Resistance in Bacteria、Vibrio bacteria research studies

ABSTRACT As clinical Salmonella enterica serovar Thompson ( S . Thompson) emerged among the top ten prevalent serovars in China, understanding the distribution and origin of its multidrug-resistant (MDR) strains becomes imperative. This study employed antimicrobial susceptibility testing, whole-genome sequencing, and bioinformatics analysis to investigate the prevalence and genomic profiles of clinically important S . Thompson ST26 across China from 1997 to 2020. Upon analyzing 141 isolates from various sources, we identified 29 isolates, derived from 25 diarrhea patients and four animal-derived foods, displayed co-resistance to ciprofloxacin, cefotaxime, and azithromycin (CIP R CTX R AZI R ), all of which are considered the front-line and critically-important antimicrobial agents for treating Salmonella infections in humans. The IncC plasmid was the predominant mobile vector identified among the CIP R CTX R AZI R isolates, harboring four crucial resistance genes qnrS1 , qepA4 , bla CMY-2 , and mph (A) that confer resistance to three critically important antimicrobials. However, the closely related and clustered IncC-harboring CIP R CTX R AZI R isolates (0–23 single nucleotide polymorphisms [SNPs]) indicated the clonal spreading of these clinically important isolates in different provinces of China. Notably, the CIP R CTX R AZI R isolates appeared in aquatic products of animal-derived food, highlighting the possibility of aquaculture practices in the emergence and transmissio...