Remote cognitive tests predict neurodegenerative biomarkers in the Insight 46 cohort

作者：Martina Del Giovane, Valentina Giunchiglia, Ziyuan Cai, Marguerite Leoni, Rebecca E Street, Kirsty Lu, Andrew Wong, Maria Popham, Jennifer Nicholas, William Trender, Peter J. Hellyer, Thomas D. Parker, Heidi Murray‐Smith, David M. Cash, Josephine Barnes, Carole H. Sudre, Paresh Malhotra, Sebastian J. Crutch, Marcus Richards, Adam Hampshire, Jonathan M. Schott · 发表于：Alzheimer s & Dementia · 年份：2025 · DOI：10.1002/alz.14572 · 被引用次数：8 · 研究领域：Dementia and Cognitive Impairment Research、Cancer-related cognitive impairment studies、Functional Brain Connectivity Studies

BACKGROUND: Alzheimer's disease-related biomarkers detect pathology years before symptoms emerge, when disease-modifying therapies might be most beneficial. Remote cognitive testing provides a means of assessing early cognitive changes. We explored the relationship between neurodegenerative biomarkers and cognition in cognitively normal individuals. METHODS: We remotely deployed 13 computerized Cognitron tasks in 255 Insight 46 participants. We generated amyloid load and positivity, white matter hyperintensity volume (WMHV), whole brain and hippocampal volumes at age 73, plus rates of change over 2 years. We examined the relationship between Cognitron, biomarkers, and standard neuropsychological tests. RESULTS: Slower response time on a delayed recognition task predicted amyloid positivity (odds ratio [OR] = 1.79, confidence interval [CI]: 1.15, 2.95), and WMHV (1.23, CI: 1.00, 1.56). Brain and hippocampal atrophy rates correlated with poorer visuospatial performance (b = -0.42, CI: -0.80, -0.05) and accuracy on immediate recognition (b = -0.01, CI: -0.012, -0.001), respectively. Standard tests correlated with Cognitron composites (rho = 0.50, p < 0.001). DISCUSSION: Remote computerized testing correlates with standard supervised assessments and holds potential for studying early cognitive changes associated with neurodegeneration. HIGHLIGHTS: 70% of the Online 46 cohort performed a set of remote online cognitive tasks. Response time and accuracy on a memory task predicted am...