Cell‐Type Specific Circuits in the Mammillary Body for Place and Object Recognition Memory

作者：Lanfang Li, Yiqing Guo, Jing Wei, Xiaomei Tang, Jinyu Zeng, Zhenye Hou, Yige Song, Aodi He, Hao Li, Ling‐Qiang Zhu, Youming Lu, Xinyan Li · 发表于：Advanced Science · 年份：2025 · DOI：10.1002/advs.202409397 · 被引用次数：4 · 研究领域：Memory and Neural Mechanisms、Neural dynamics and brain function、Neuroscience and Neuropharmacology Research

Mammillary body (MB) is traditionally viewed as a structural node of an anatomic circuit for emotion and memory. However, little is known about its molecular and cellular organizations. Here, a discovery that MB contains four subtypes of neurons that occupy different spatial subregions is reported. Of these, two subtypes of neurons are tagged by parvalbumin (PV) and dopamine receptor-D2 (Drd2) markers. PV neurons are spontaneously active, whereas Drd2 neurons are inactive at rest and generate rebound bursts. These two distinct electrophysiological properties are encoded by Kcnn4 and Cacna1h. PV and Drd2 neurons generate two distinct cell-type specific circuits by receiving inputs from two discrete subiculum neuronal classes. Gain- and loss-of-function studies on these cortical-subcortical circuits demonstrate their differential roles for place and object recognition memory. This finding provides a comprehensive molecular and structural atlas of MB neurons at single-cell resolution and reveals that MB contains molecularly, structurally, and functionally dissociable streams within its serial architecture.