The conditions that patients with systemic lupus erythematosus should fulfill before pregnancy to optimize outcomes: a large-scale multicenter cohort study from China

作者：Xueyang Zhang, Lingshan Liu, Shudian Lin, Xinwang Duan, Hui Luo, Yongfu Wang, Zhenbiao Wu, Can Huang, Yin Long, Yixin Cui, Xiaohua Shi, Yijun Song, Juntao Liu, Xiaofeng Zeng, Jiuliang Zhao, Mengtao Li, Xinping Tian · 发表于：Arthritis Research & Therapy · 年份：2025 · DOI：10.1186/s13075-025-03497-9 · 被引用次数：11 · 研究领域：Systemic Lupus Erythematosus Research、Pregnancy and Medication Impact、Liver Diseases and Immunity

BACKGROUND: Systemic lupus erythematosus (SLE) is frequently associated with a lower rate of live birth and a higher incidence of adverse pregnancy outcomes (APOs), and pregnancy can also increase the risk of SLE flares. Comprehensive preconception assessment is critical for improved pregnancy outcomes in patients with SLE. Unfortunately, no global consensus on the conditions that patients with SLE should fulfill prior to pregnancy has yet been formed. OBJECTIVE: This study aimed to investigate the conditions that patients with SLE should fulfill before pregnancy to optimize outcomes. STUDY DESIGN: This was a retrospective study utilizing data from a multicenter Chinese SLE cohort. Information on demographics, obstetric history, SLE activity, clinical manifestations, autoantibody profiles, laboratory parameters, therapeutics, and pregnancy outcomes was collected. Logistic regression was used to explore the optimal conditions. RESULTS: The study comprised 347 singleton pregnancies from 332 patients with SLE in total, with a mean maternal age at conception of 30.3 (SD 4.0) years. The analysis revealed that patients who were stable for at least 6 months, had no active vital organ involvement, were on nonfluorinated corticosteroids no more than the dose equivalent to prednisone 7.5 mg per day, and were on hydroxychloroquine displayed a significantly higher incidence of live birth (86.1% vs. 73.7%, p = 0.004) and a markedly decreased risk of APOs (29.4% vs. 52.1%, p < 0.001). Addi...