eIF3a function in immunity and protection against severe sepsis by regulating B cell quantity and function through m6A modification

作者：Qianying Ouyang, Jiajia Cui, Yang Wang, Ke Liu, Yan Zhan, Wei Zhuo, Juan Chen, Hong-Hao Zhou, Chen‐Hui Luo, Jianming Xia, Lian‐Sheng Wang, Chengxian Guo, Jianting Zhang, Zhao-Qian Liu, Ji‐Ye Yin · 发表于：Acta Pharmaceutica Sinica B · 年份：2025 · DOI：10.1016/j.apsb.2025.02.005 · 被引用次数：7 · 研究领域：RNA modifications and cancer、Peptidase Inhibition and Analysis、RNA Interference and Gene Delivery

A modification of mRNAs. These findings unveil a novel mechanism underlying sepsis, implicating the pivotal role of B cells in this complex disease process regulated by eIF3a. Furthermore, eIF3a may be used to develop a potential strategy for treating sepsis.