Inflammatory Bowel Disease and Dementia: Evidence Triangulation from a Meta-Analysis of Observational Studies and Mendelian Randomization Study.

作者：Di Liu, Mei Ling Cao, Shan Wu, Bing Li, Yi Jiang, Teng Lin, Fu Li, Wei Cao, Jin Qiu Yuan, Feng Sha, Zhicheng Yang, Jin Tang · 发表于：PubMed · 年份：2025 · DOI：10.3967/bes2024.149 · 被引用次数：2 · 研究领域：Inflammatory Bowel Disease、Genetic Associations and Epidemiology、Barrier Structure and Function Studies

Objective: Observational studies have found associations between inflammatory bowel disease (IBD) and the risk of dementia, including Alzheimer's dementia (AD) and vascular dementia (VD); however, these findings are inconsistent. It remains unclear whether these associations are causal. Methods: We conducted a meta-analysis by systematically searching for observational studies on the association between IBD and dementia. Mendelian randomization (MR) analysis based on summary genome-wide association studies (GWASs) was performed. Genetic correlation and Bayesian co-localization analyses were used to provide robust genetic evidence. Results: = 0.97-1.07). In addition, genetic correlation and co-localization analyses did not reveal any genetic associations between IBD and dementia. Conclusion: Our study did not provide genetic evidence for a causal association between IBD and dementia risk. The increased risk of dementia observed in observational studies may be attributed to unobserved confounding factors or detection bias.