Efferocytosis and inflammation: a bibliometric and systematic analysis

作者：Xin Cao, Fen Li, Xi Xie, Guanghui Ling, Xiaoyu Tang, Wenfang He, Jing Tian, Yan Ge · 发表于：Frontiers in Medicine · 年份：2025 · DOI：10.3389/fmed.2025.1498503 · 被引用次数：7 · 研究领域：Phagocytosis and Immune Regulation、Erythrocyte Function and Pathophysiology、Immune responses and vaccinations

Objective: To visualize and analyze the trends and hotspots of efferocytosis and inflammation via bibliometric methods. Methods: Relevant articles and reviews from 2006 to 2023 were retrieved from the Web of Science Core Collection. The data were processed with CiteSpace, and some graphs were generated with Microsoft Excel (version 2016), VOSviewer, Scimago Graphica, Bibliometrix and R Studio. Results: A total of 1,003 papers were included, revealing a significant upward trend in efferocytosis and inflammation research. The United States (456, 45.46%), China (164, 16.35%) and the United Kingdom (99, 9.87%) were the three countries with the highest numbers of publications. Harvard University (84, 6.74%) contributes the most out of the top 5 institutions. Among the researchers in this field, Serhan CN was the author with the highest number of articles in the field (35, 3.49%), and deCathelineau AM first named "efferocytosis" in 2003. Keyword analysis identified "activation," "tam receptors," "docosahexaenoic acid" "systemic lupus erythematosus," "myocardial infarction" and "alveolar macrophages" as core topics, indicating a concentrated trend in the mechanism of physiological state and inflammatory diseases such as autoimmune, cardiovascular, and pulmonary diseases. The latest surge words "inflammation resolution" and "cancer" in the keyword heatmap indicate future research directions. Conclusion: Research on the association between efferocytosis and inflammation has been a pro...