Cone mosaic in eyes with varied axial length using adaptive optics scanning laser ophthalmoscopy

作者：Wen‐Da Zhou, Li Dong, Han-Xu Shi, Ruiheng Zhang, Yuhang Yang, Hanqing Zhao, Yi-Tong Li, Chuyao Yu, Heyan Li, Haotian Wu, Lei Shao, Wenbin Wei · 发表于：Photodiagnosis and Photodynamic Therapy · 年份：2025 · DOI：10.1016/j.pdpdt.2025.104517 · 被引用次数：3 · 研究领域：Ophthalmology and Visual Impairment Studies、Glaucoma and retinal disorders、Optical Coherence Tomography Applications

• This study used the world's first commercial adaptive optics scanning laser ophthalmoscope (AOSLO) to redefine cone regularity and cone dispersion, elucidating their relationships with axial elongation and cone density, and offering novel insights for clinical applications in preclinical pathologic myopia management. • Using non-invasive adaptive optics technology, the research examined photoreceptor topography alterations associated with axial myopia, providing new perspectives on its pathogenesis. • This study established the first cone mosaic dataset in clinically healthy Chinese individuals across a range of axial lengths, rigorously excluding potential confounding factors such as macular degenerative and dystrophic diseases. Abnormalities in cone photoreceptor topography are closely associated with the development of various ocular diseases, including axial myopia. Adaptive Optics Scanning Laser Ophthalmoscopy (AOSLO) enables high-resolution, single-cell imaging of the living human retina. This study aimed to investigate the potential relationship between cone topography and axial myopia using a commercial AOSLO system. A total of 74 participants (148 eyes; 30 men, 40.5 %) with a mean age of 31.8 ± 10.4 years were included. Cone mosaics were imaged at 3° and 5° eccentricities of the fovea centralis. The relationships between cone parameters (linear cone density, cone spacing, cone dispersion, and cone regularity) and axial length were analyzed. Linear cone density sign...