NIR-II imaging-based detection of early changes in lower limb perfusion in type 2 diabetes patients without peripheral artery disease

作者：Yijie Ning, Jie Hu, Yikun Zhu, Wei Tang, Sheng Yan, Haifeng Li, Zeyu Zhang, Chuanlong Lu, Keyao Ren, Peilu Shi, Yao Tian, Qian Wang, Yan Zhao, Tingting Gao, Ruijing Zhang, Honglin Dong · 发表于：Diabetes Research and Clinical Practice · 年份：2025 · DOI：10.1016/j.diabres.2025.112038 · 被引用次数：6 · 研究领域：Peripheral Artery Disease Management、Infrared Thermography in Medicine、Optical Imaging and Spectroscopy Techniques

AIMS: The formation of lower limb arterial plaques, exacerbated by type 2 diabetes (T2D), represents an early stage of lower limb peripheral artery disease (PAD). Second near-infrared region (NIR-II) imaging is an emerging technique with high sensitivity for detecting perfusion levels. This study explores the value of NIR-II imaging in identifying perfusion changes due to lower extremity arterial plaques in T2D patients without PAD. METHODS: NIR-II imaging with indocyanine green (ICG) was conducted on 120 T2D patients, who were categorized into two groups: plaque and non-plaque. NIR-II parameters and clinical characteristics were analyzed between the two groups to identify significant predictors of lower extremity arterial plaques. RESULTS: Six NIR-II imaging parameters (T start, T 1/2, Tmax, Ingress rate, Egress, and Egress rate) showed significant differences and diagnostic efficacy between the two groups. Three NIR-II parameters (T start, Egress, and Egress rate) and two clinical characteristics (age and sex) were identified as independent predictors of lower limb artery plaques. The nomogram showed that a combined model with NIR-II parameters and clinical characteristics exhibited higher diagnostic efficacy. CONCLUSION: NIR-II imaging can effectively detect early perfusion changes in T2D patients, showing great potential for pre-diagnosis of individuals at high risk for PAD.