Age‐Based Classification and Outcomes in Pediatric Heart Failure: Findings From a Retrospective Multicenter Cohort Study

作者：Yuxing Yuan, Bo Pan, Fangjie Wang, Zhi Chen, Ying Guo, Xing Shen, Xue‐cun Liang, Xue‐cun Liang, Yanyan Liang, Yanlin Xing, Huili Zhang, Ying-Qian Zhang, Chunhong Xie, Li Li, Zhilin Huang, Huichao Sun, Min Zheng, Lingjuan Liu, Tiewei Lv, Zipu Li, Xiaohua Liang, Xiaohua Liang, Jie Tian · 发表于：Journal of the American Heart Association · 年份：2025 · DOI：10.1161/jaha.124.038129 · 被引用次数：10 · 研究领域：Heart Failure Treatment and Management、Congenital Heart Disease Studies、Cardiomyopathy and Myosin Studies

Background Although heart failure is a well‐known major global public health concern, the general understanding of the clinical status of pediatric heart failure (PHF) is inadequate. Therefore, this study aims to enhance the general understanding of clinical characteristics across different PHF age groups and provide references for improving PHF treatment strategies. Methods This multicenter retrospective cohort study involved patients from 20 Chinese provinces, primarily including hospitalized patients (aged ≤18 years) diagnosed with heart failure between January 2013 and December 2022. The study subjects were categorized into 4 groups: neonatal, infant and toddler, young children, and adolescent. Results Herein, 2903 hospitalized patients with PHF were included. Significant differences were observed across age groups in clinical characteristics, auxiliary examination results, comorbid diagnoses, and hospitalization outcomes. After adjusting for covariates, the odds of in‐hospital death were significantly lower in the infant and toddler (odds ratio [OR], 0.46 [95% CI, 0.25–0.85]), young children (OR, 0.39 [95% CI, 0.18–0.85]), and adolescent (OR, 0.34 [95% CI, 0.13–0.87]) groups compared with the neonatal group. Furthermore, the odds of cardiovascular adverse events were significantly higher in the young children (OR, 1.91 [95% CI, 1.62–2.88]) and adolescent (OR, 2.16 [95% CI, 1.15–4.06]) groups compared with the neonatal group. Additionally, regarding the odds of a bad Ross...