Research trends in glioma chemoradiotherapy resistance: a bibliometric analysis (2003–2023)

作者：Shishi Yu, J.-H. Wu, Yuan Jing, Peter Ping Lin, Lang Lang, Yifan Xiong, Wangzhong Chen, Wenhua Liu, Changpeng Sun, Yuntao Lu · 发表于：Frontiers in Oncology · 年份：2025 · DOI：10.3389/fonc.2025.1539937 · 被引用次数：1 · 研究领域：Glioma Diagnosis and Treatment、Ferroptosis and cancer prognosis、Radiomics and Machine Learning in Medical Imaging

Background: Glioma is the most aggressive primary malignant tumor of the central nervous system, characterized by high recurrence rates and resistance to chemoradiotherapy, making therapeutic resistance a major challenge in neuro-oncology. Recent research emphasizes the role of the tumor microenvironment (TME) and immune modulation in glioma progression and resistance. Despite these advances, a comprehensive bibliometric analysis of research trends in glioma chemoradiotherapy resistance over the past two decades is lacking. This study aims to systematically evaluate the research landscape, identify emerging hotspots, and provide guidance for future investigations. Methods: Articles on glioma chemoradiotherapy resistance published between 2003 and 2023 were retrieved from the Web of Science Core Collection, resulting in 4,528 publications. Bibliometric tools, including VOSviewer, CiteSpace, and R packages such as bibliometrix and ggplot2, were used to analyze co-authorship networks, keyword evolution, and citation bursts to identify collaboration patterns, thematic developments, and influential contributions. Results: Publication output increased significantly between 2013 and 2022, peaking at 650 articles in 2022. Over 1,000 institutions from 88 countries contributed to this research. The United States, Switzerland, and Germany showed the highest citation impact, while China led in publication volume but demonstrated relatively lower citation influence. The research focus has...