Iron-Catalyzed Ipso -Nitration of Aryl Borides via Visible-Light-Induced β-Homolysis

作者：Shuyang Liu, Shuyang Liu, Yusheng Lu, Hongyao Wang, Zhiyan Xue, Ziyi Xu, Huihui Wan, Qingxin Yin, Tianming Lv, Shu-Xin Liu, Shu-Xin Liu, Yunhe Jin · 发表于：ACS Catalysis · 年份：2025 · DOI：10.1021/acscatal.4c07252 · 被引用次数：25 · 研究领域：Radical Photochemical Reactions、Catalytic C–H Functionalization Methods、Catalytic Cross-Coupling Reactions

High Resolution Image Download MS PowerPoint Slide Herein, we reported a practical method to realize ipso -nitration of boronic acids, their pinacol esters, and trifluoroborate salts with alkali metal salt NaNO 3 as a nitrating reagent. A Fe III /Fe IV catalytic cycle involving an unusual visible-light-induced β-homolysis pathway of the N–O bond in a simple iron complex effectively provides a nitryl radical as the key nitrating species. This protocol bears mild reaction conditions, a broad scope (up to 99% yield), good functional group compatibility, and convenient scale-up synthesis.