Interactions between human immunodeficiency virus and human endogenous retroviruses

作者：Mengying Li, Fengting Yu, Baoli Zhu, Xiao Jiang, Yan Chang, Xiaojie Yang, Xuelei Liang, Fang Wang, Hanxi Zhang, Fujie Zhang · 发表于：Journal of Virology · 年份：2025 · DOI：10.1128/jvi.02319-24 · 被引用次数：7 · 研究领域：HIV Research and Treatment、Chromosomal and Genetic Variations、T-cell and B-cell Immunology

ABSTRACT Human immunodeficiency virus (HIV), a retrovirus of the Lentivirus genus, targets CD4 + T cells, causing immune dysfunction and AIDS. Approximately 8% of the human genome consists of human endogenous retroviruses (HERVs), ancient retroviral remnants that may interact with HIV. Despite antiretroviral therapy, challenges such as drug resistance, poor immune reconstitution (PIR), and reservoirs remain. This GEM discusses the impact of HIV on HERVs, the potential roles of HERVs in PIR and reservoirs, and provides insights into future research directions.