Debut of enzyme-responsive anionic cyanine for overlap-free NIR-II-to-I dual-channel tumour imaging

作者：Feiyi Chu, Bin Feng, Yiyang Zhou, Min Liu, Hailiang Zhang, Meihui Liu, Qian Chen, Shengwang Zhang, Yeshuo Ma, Jie Dong, Fei Chen, Wenbin Zeng · 发表于：Chemical Science · 年份：2025 · DOI：10.1039/d4sc06459c · 被引用次数：10 · 研究领域：Nanoplatforms for cancer theranostics、Luminescence and Fluorescent Materials、Lanthanide and Transition Metal Complexes

systemic circulation vessel outlining and microvascular imaging. At the tumour site with GGT over expression, an intramolecular S,N-rearrangement would initiate the conversion of sulphur-substituted cyanine to amino-substituted cyanine, resulting in a significant emission shift of 270 nm. Using the dual-channel signal changes, CFC-GSH effectively differentiates between subcutaneous hepatocellular carcinoma (HCC) and normal tissue and precisely localizes metastatic HCC tumours in the abdominal cavity. These results reveal that CFC-GSH exhibits promising potential as a multiprospective candidate tool for fluorescence screening and diagnostic imaging in various biological scenarios.