KLF4: a multifunctional nexus connecting tumor progression and immune regulation

作者：Ying Ju, Wen Xiao, Bryan J. Mathis, Ying Shi · 发表于：Frontiers in Immunology · 年份：2025 · DOI：10.3389/fimmu.2025.1514780 · 被引用次数：11 · 研究领域：Kruppel-like factors research、Cancer-related gene regulation、Genetic Syndromes and Imprinting

Krüppel-like factors (KLFs) regulate various biological processes such as cell proliferation, migration, invasion, and differentiation as gene transcription factors. Signaling pathways which mediated by KLF4 and KLF4 have a sophisticated role in tumors due to multiple factors, including the types or stage of tumors. KLF4 plays a promoter role in tumorigenesis and development, or tumor suppressor as a context-dependent anti- and pro-inflammatory factor. KLF4 over-expression increases CD8+T cell differentiation and enhances the antitumor immunity. This review aims to provide information about the relationship of KLF4 in immunity with tumors and to guide the future study.