Sex disparity in the association between alcohol consumption and sarcopenia: a population-based study

作者：Longbao Yang, Qiuju Ran, Yee Hui Yeo, Wen Zhang, Shuyue Tuo, Yong Li, Jia Yuan, Shejiao Dai, Jinhai Wang, Fanpu Ji, Xinxing Tantai · 发表于：Frontiers in Nutrition · 年份：2025 · DOI：10.3389/fnut.2025.1536488 · 被引用次数：3 · 研究领域：Alcohol Consumption and Health Effects、Nutrition and Health in Aging、Alcoholism and Thiamine Deficiency

Background: Previous studies have shown inconsistent findings regarding the association of alcohol consumption with sarcopenia. Therefore, this study comprehensively investigated the association of alcohol consumption with sarcopenia in a nationally representative sample of US adults. Methods: This population-based study included adults aged 18 years and older from the National Health and Nutrition Examination Survey (NHANES) III. Alcohol exposure was defined as daily alcohol intake, alcohol drinking history, number of drinking days per week, and frequency of binge drinking days per month. Weighted logistic regressions were used to determine associations. Results: = 7,649), corresponding to alcohol exposure categories of daily alcohol intake, drinking history, number of drinking days per week, and frequency of binge drinking days per month. In the full model, the risk of sarcopenia was significantly associated with mild (odds ratio [OR]: 1.65; 95% confidence interval [CI]: 1.08-2.51), moderate (OR: 2.04; 95% CI: 1.12-3.71), and heavy drinkers (OR: 2.42; 95% CI: 1.17-4.97) compared to nondrinkers. There was an association between the development of sarcopenia and current drinkers (OR: 1.69; 95% CI: 1.12-2.56) but not former drinkers (OR: 1.21; 95% CI: 0.88-1.66). Compared to nondrinkers, an increased risk of developing sarcopenia was observed in participants who consumed alcohol 2 days (OR: 2.36; 95% CI: 1.40-3.99) or > 2 days (OR: 1.84; 95% CI: 1.10-3.07) per week, and those ...