Association of Sleep Duration With Serum Estradiol Concentrations Among American Men and Women: Evidence From NHANES 2013–2016

作者：Zhisheng Zhu, Shiquan Wu, Xingong Lin, Chaoyang Wang, Xianying Zhou · 发表于：International Journal of Endocrinology · 年份：2025 · DOI：10.1155/ije/7863420 · 被引用次数：1 · 研究领域：Sleep and related disorders、Circadian rhythm and melatonin、Sleep and Wakefulness Research

Objective: To evaluate the association between sleep duration with serum estradiol concentrations and its variation by sex and age in American adults. Methods: Data were analyzed for 5406 men and women (≥ 20 years old) who participated in the cycles of the National Health and Nutrition Examination Survey 2013–2016, a cross‐sectional study. Total estradiol (pg/mL) was measured and categorized (low, normal, and high) based on the NHANES protocol. Sleep duration was classified as ≤ 6, 6–9, and ≥ 9 h. Weighted multivariable adjusted and multinomial logistic regression models were conducted to assess these associations. Results: Our multivariable multinomial logistic regression analysis revealed no significant associations between sleep duration and serum estradiol concentrations among both American men and women. Specifically, comparisons of sleep durations (≤ 6 and ≥ 9 h) to the reference group (6–9 h) across various age categories showed odds ratios for low and high estradiol concentrations that remained statistically nonsignificant in fully adjusted models. These findings suggest that, unlike previous studies linking sleep duration with variations in other hormones, estradiol concentrations do not appear to be significantly affected by differences in sleep duration in either sex across all age groups studied. Conclusion: The lack of significant associations between sleep duration and serum estradiol concentrations indicates that sleep duration may not influence estradiol level...