Carnosic acid reduces lipid content, enhances gut health, and modulates microbiota composition and metabolism in diet-induced obese mice

作者：Jing Zhang, Meng-Zhu Shen, Yue Yin, Yuru Chen, Xianying Deng, Jingyun Mo, Xiaoling Zhou, Juanying Lin, Xinxin Chen, Xinxin Chen, Xinwei Xie, Xian Wu, Xuexiang Chen, Xuexiang Chen · 发表于：Food & Function · 年份：2025 · DOI：10.1039/d4fo04534c · 被引用次数：8 · 研究领域：Biochemical effects in animals、Phytochemicals and Antioxidant Activities、Biochemical Analysis and Sensing Techniques

being the dominant bacterium negatively correlated with obesity and various fecal metabolites. Regarding the intestinal barrier function, CA promoted the expression of tight junction proteins and inhibited the TLR4/MyD88/NF-κB signaling pathway in obese mice to alleviate colonic inflammation. These results suggest that CA improved multiple aspects of gut health in diet-induced obesity in mice, providing a scientific basis for future clinical studies in humans.