Reliable Monitoring of Respiratory Function with Home Spirometry in People Living with Amyotrophic Lateral Sclerosis

作者：Julian Peller, Marcos A. Trevisan, Gastón Bujía, Felipe Aguirre, Diego E. Shalóm, Alan Taitz, Stephanie Henze, Silviya Bastola, Jason Osik, Ryan A. Shewcraft, Peng Jiang, Joel Schwartz, Terry Heiman‐Patterson, Michael Sherman, Matthew F. Wipperman, Oren Levy, Guofa Shou, Karl Sillay, Lyle W. Ostrow, Ernest Fraenkel, James D. Berry, Indu Navar Bingham, Esteban G. Roitberg · 发表于：medRxiv · 年份：2025 · DOI：10.1101/2025.02.03.25321333 · 研究领域：Amyotrophic Lateral Sclerosis Research

Monitoring respiratory function is essential for assessing the progression of Amyotrophic Lateral Sclerosis (ALS) and planning interventions. Using spirometry data from the Radcliff Study —a fully remote, longitudinal, exploratory study with a cohort of 67 pALS—we demonstrate that flexible coaching, combined with a quality control analysis that excludes values of ‘0’ and timepoints with failed measurement trials, produces consistent remote spirometry results. Our findings indicate that home-measured Slow Vital Capacity (SVC) and Forced Vital Capacity (FVC) evolve similarly and progress linearly over the study period (7.7 ± 4.0 months). This remains true in both slow and fast progressor subpopulations. This observed linearity in respiratory trajectories supports the potential for early, accurate estimation of progression, reinforcing the feasibility of less frequent monitoring without compromising assessment precision, and reducing the burden on both pALS and the healthcare system. Furthermore, our results align with reported in-clinic pulmonary tests, validating remote monitoring as a means to promote more equitable and accessible clinical trial designs.