Granzyme K activates the entire complement cascade

作者：Carlos A. Donado, Erin Theisen, Fan Zhang, Aparna Nathan, Madison L. Fairfield, Karishma Vijay Rupani, Dominique Jones, Kellsey Johannes, Accelerating Medicines Partnership RA/SLE Network, Jennifer S. Albrecht, Jennifer H. Anolik, William A. Apruzzese, Jennifer L. Barnas, Joan M. Bathon, Ami Ben‐Artzi, Brendan F. Boyce, David L. Boyle, S. Louis Bridges, Vivian P. Bykerk, Debbie Campbell, Arnold Ceponis, Adam T. Chicoine, Michelle L. Curtis, Kevin D. Deane, Edward F. DiCarlo, Laura T. Donlin, Patrick J. Dunn, Andrew D. Filer, Hayley L. Carr, Gary S. Firestein, Lindsy J. Forbess, Laura B. Geraldino-Pardilla, Susan M. Goodman, Ellen M. Gravallese, Deepak A. Rao, Peter K. Gregersen, Joel M. Guthridge, María Gutiérrez‐Arcelus, V. Michael Holers, Diane Michelle Horowitz, Laura B. Hughes, Lionel B. Ivashkiv, Kazuyoshi Ishigaki, Judith A. James, Joyce B. Kang, Gregory Keras, Amit Lakhanpal, James Arthur Lederer, Myles Lewis, Yuhong Li, Katherine P. Liao, Arthur M. Mandelin, Ian Mantel, Kathryne E. Marks, Mark Maybury, Andrew McDavid, Mandy J. McGeachy, Joseph Mears, Nida Meednu, Nghia Millard, Larry W. Moreland, Saba Nayar, Alessandra Nerviani, Dana E. Orange, Harris Perlman, Costantino Pitzalis, Javier Rangel‐Moreno, Karim Raza, Yakir Reshef, Christopher T. Ritchlin, Felice Rivellese, William H. Robinson, Laurie Rumker, Ilfita Sahbudin, Saori Sakaue, Jennifer A. Seifert, Dagmar Scheel‐Toellner, Anvita Singaraju, Kamil Slowikowski, Melanie H. Smith, Darren Tabechian, Paul J. Utz, Kathryn Weinand, Dana Weisenfeld, Michael H. Weisman, Qian Xiao, Zhu Zhu, Zhihan J. Li, Andrew C. Cordle, Aaron J. Wyse, Soumya Raychaudhuri, Daniel F. Dwyer, Anna Helena Jonsson, Michael B. Brenner · 发表于：Nature · 年份：2025 · DOI：10.1038/s41586-025-08713-9 · 被引用次数：130 · 研究领域：Complement system in diseases、Renal Diseases and Glomerulopathies、Apelin-related biomedical research