The therapeutic potential of exercise in post-traumatic stress disorder and its underlying mechanisms: A living systematic review of human and non-human studies

作者：Simonne Wright, Virginia Chiocchia, Olufisayo Elugbadebo, Simple Ouma, Toshi A. Furukawa, Claire Friedrich, Charlotte Austin, Hossein Dehdarirad, David G. Gilbert, Jaycee Kennett, Edoardo G. Ostinelli, Jennifer Potts, Fiona Ramage, Emily S. Sena, Spyridon Siafis, Claire Stansfield, James Thomas, Francesca Tinsdeall, Thomy Tonia, Malcolm Macleod, Andrea Cipriani, Georgia Salanti, Soraya Seedat · 发表于：Wellcome Open Research · 年份：2025 · DOI：10.12688/wellcomeopenres.23033.2 · 被引用次数：3 · 研究领域：Posttraumatic Stress Disorder Research、Stress Responses and Cortisol、Traumatic Brain Injury Research

Background: Exercise for post-traumatic stress disorder (PTSD) is a potentially effective adjunct to psychotherapy. However, the biopsychosocial mechanisms of exercise are not well understood. This co-produced living systematic review synthesizes evidence from human and non-human studies. Methods: We Included controlled human and non-human studies involving searches of multiple electronic databases (until 31.10.23). Records were screened, extracted, assessed for risk of bias, and reconciled by two independent reviewers. The primary outcome for human studies was PTSD symptom severity, while outcomes of interest for non-human studies included freezing behaviour, fear memory, fear generalization, startle response, and locomotion. Data were synthesised with random-effects meta-analysis. Results: Eleven human studies and 14 non-human studies met the eligibility criteria. Results of human studies showed that exercise was not associated with symptom severity improvement compared to control (standardized mean difference [SMD] -0.08, 95% confidence interval [CI] -0.24 to 0.07). High-intensity exercise reduced PTSD symptoms scores more than moderate-intensity exercise. There was insufficient data to examine the effects of exercise on functional impairment, PTSD symptom clusters, and PTSD remission. Only three studies, all at high risk of bias, examined mechanisms of exercise with inconclusive results. Results of non-human studies showed that exercise was associated with improvement in ...