Associations between nutrient intake and osteoarthritis based on NHANES 1999 to 2018 cross sectional study

作者：Xiaofeng Lv, Xinmin Deng, Rui Lai, Shanshan Liu, Zihao Zou, Xuechun Dai, Yalan Luo, Jianjun Luo, Ying Li · 发表于：Scientific Reports · 年份：2025 · DOI：10.1038/s41598-025-88847-y · 被引用次数：7 · 研究领域：Nutritional Studies and Diet、Nutrition and Health in Aging

The relationship between nutrient intake and osteoarthritis (OA) remains unclear. This study utilized data from the National Health and Nutrition Examination Survey (NHANES) in a multi-cycle retrospective cohort study to explore the associations between the intake of six nutrients-carbohydrates, dietary fiber, protein, fat, folate, niacin and OA. This study performed a cross-sectional analysis using NHANES data from 1999 to 2018 to investigate the relationship between the intake of six nutrients and OA. Univariate and multivariate weighted logistic regression models, along with restricted cubic splines (RCS), were applied to assess the associations between nutrient intake and OA. A total of 32,484 participants were included in the study, of whom 1864 were diagnosed with OA, resulting in a prevalence rate of 5.74%. Multivariate weighted logistic regression consistently demonstrated that dietary fiber, folic acid, and nicotinic acid intake were negatively associated with the presence of OA, while protein intake exhibited a J-shaped relationship with OA, and carbohydrate or fat intake showed no significant association with OA. Compared with participants in the lowest quartile (Q1), those in the highest quartile (Q4) of dietary fiber, folic acid, and nicotinic acid intake had 27%, 28%, and 33% lower odds of having OA, respectively, after adjusting for potential confounding factors. RCS analysis revealed that dietary fiber and nicotinic acid intake had a nonlinear relationship wit...