Electrocatalytic Alkene Hydrogenation/Deuteration

作者：Faxiang Bu, Yuqi Deng, Lijun Lu, Yan Li, Wenxu Song, Zhaoliang Yang, Xu Luo, Xin Dong, Ran Yi, Dali Yang, Shengchun Wang, Aiwen Lei, Wu Li · 发表于：Journal of the American Chemical Society · 年份：2025 · DOI：10.1021/jacs.4c14320 · 被引用次数：44 · 研究领域：Chemical Reactions and Isotopes、Asymmetric Hydrogenation and Catalysis、Ammonia Synthesis and Nitrogen Reduction

Traditional reductions of alkenes, such as using stoichiometric reductants with waste generation and catalytic hydrogenation with high-pressure H 2, are accompanied by environmental or safety issues. Herein, we demonstrated a universal method for the electrocatalytic hydrogenation and deuteration of alkenes with modified electrodes under ambient temperature. The key M-H/M-D species for alkene reduction were generated from the electrolysis of H 2 O/D 2 O on modified electrodes, which avoided the usage of H 2 and D 2 . Mono-, di-, tri-, and tetra-substituted alkenes were successfully reduced in this electrocatalytic system using H 2 O and D 2 O as hydrogen and deuterium sources. Electron-donating/-withdrawing alkenes, alkenes with other easily reducible functional groups, and complicated natural products and drugs were all reductive hydrogenated and deuterated with excellent yields (85 examples, yields up to 99%). Faraday efficiency of this efficient method could reach 84%. Moreover, the catalytic amount of metal could decrease to less than 0.01 mol %.