Development of a scalable and sustainable continuous-flow microreaction process for mononitration of aromatic compounds with high selectivity and yield

作者：Dong Xing, Xiangui Lei, Yufeng Fu, Zhijie Xu, Dengyun Luo, Jiujun Chen, Yong Xiang, Zhouyu Wang, Qiao Song · 发表于：RSC Advances · 年份：2025 · DOI：10.1039/d4ra09115a · 被引用次数：6 · 研究领域：Nanomaterials for catalytic reactions、Innovative Microfluidic and Catalytic Techniques Innovation、Catalytic Processes in Materials Science

. Under the same reaction conditions, the yield and selectivity were consistent with, or even improved over, those obtained in small-scale experiments, demonstrating the scalability and industrial potential of the process. Additionally, the process incorporates a waste acid recycling strategy, which has no significant impact on product yield, thus enhancing economic benefits and reducing environmental pollution. This continuous nitration process not only shows broad application potential but also offers a safe and efficient solution for nitration in the pharmaceutical and chemical industries.