Association of lung health and cardiovascular health (Life’s Essential 8)

作者：Wanjia Zhang, Menglong Zou, Junyao Liang, Dexu Zhang, Man Zhou, Hui Feng, Chusen Tang, Jie Xiao, Zhan Yi, Xu-Cheng Yin · 发表于：Frontiers in Medicine · 年份：2025 · DOI：10.3389/fmed.2025.1481213 · 被引用次数：4 · 研究领域：Cardiovascular Health and Risk Factors、Delphi Technique in Research、Health, Environment, Cognitive Aging

Background: Cardiorespiratory health issues often intersect. This study explored the relationship between lung health and the recently updated Cardiovascular Health Measure (Life's Essential 8). Methods: = 3,449). LE8 scores were used as both continuous and categorical variables (0-49, 50-79, 80-100). Weighted multivariate regression analyses examined the correlations between LE8 and lung health, and weighted restricted cubic spline (RCS) regression analyzed potential non-linear relationships. Subgroup analysis was conducted to verify stability. Results: Overall lung health was better in the high LE8 group than in the low LE8 group. In the fully adjusted model, the high LE8 group had significantly lower odds of asthma (OR = 0.42; 95% CI = 0.29, 0.59) and chronic bronchitis (OR = 0.27; 95% CI = 0.15, 0.49) compared to the low LE8 group. Regarding lung function, each 10-point increase in LE8 was associated with an increase of 50 ml in FEV1 (Beta = 50; 95% CI = 32, 67) and 56 ml in FVC (Beta = 56; 95% CI = 32, 79). Among middle-aged and older adults (age > 40), the high LE8 group had significantly lower odds of respiratory symptoms, including cough (OR = 0.23; 95% CI = 0.12, 0.46), phlegm (OR = 0.42; 95% CI = 0.19, 0.90), and wheezing (OR = 0.29; 95% CI = 0.15, 0.54). RCS analyses demonstrated a non-linear negative correlation between LE8 and cough, sputum, and wheeze. Subgroup and sensitivity analysis suggested stability. Conclusion: Life's Essential 8 (LE8) scores are positive...