Glioma stem cell membrane-camouflaged photothermal nanozyme for synergistic antitumor via dual-targeted drug delivery across blood-brain barrier

作者：Jialiang Lin, Zesheng Sun, Yue Huang, Qianqian Liu, Mujie Shen, Chunbin Shao, Weiquan Liao, Yu Yang, Yan Song, Yi Wang, Rongqin Huang, Jinlong Shi · 发表于：Chemical Engineering Journal · 年份：2025 · DOI：10.1016/j.cej.2025.160181 · 被引用次数：16 · 研究领域：Nanoplatforms for cancer theranostics、Advanced Nanomaterials in Catalysis、Extracellular vesicles in disease

The schematic diagram illustrates the synthesis pathway of the biomimetic nanoenzyme (D@FNMG) and the mechanism of killing glioma cells through combination therapy. • A photothermal nanozyme camouflaged by glioma stem cell membrane was constructed. • Targeted drug delivery across the BBB to both GBM cells and GSC was achieved. • The chemotherapy-CDT-PTT combined therapy promoted tumor apoptosis and ferroptosis. • Demonstrated significant tumor inhibition and survival extension with good biosafety. Glioma stem cells (GSC) are key contributors to the high resistance and recurrence of glioblastoma multiforme (GBM), while the blood–brain barrier (BBB) hinders drug delivery to GBM. In response to these challenges, we have developed a photothermal nanozyme drug delivery system camouflaged with glioma stem cell membrane (GSCM) to synergistically combat GBM. This system employs iron–nitrogen-doped mesoporous carbon nanospheres (FNM) as carriers for doxorubicin (DOX), encapsulated within GSCM. This nanomaterial utilizes GSCM to cross the BBB, target both GSC and GBM cells release DOX under the acidic conditions of the tumor microenvironment (TME) to facilitate chemotherapy. Notably, the system’s inherent peroxidase-like activity catalyzes the conversion of H 2 O 2 into reactive oxygen species (ROS), boosting the level of oxidative stress and promoting tumor cell apoptosis and ferroptosis, thereby synergistically achieving chemodynamic therapy (CDT). Moreover, under near-infrared (NIR)...