Quinazolinones as Potential Anticancer Agents: Synthesis and Action Mechanisms

作者：Zhijiang Deng, Jieming Li, Pengbo Zhu, Jie Wang, Yuanfang Kong, Yulong Hu, Juntao Cai, Chunhong Dong · 发表于：Biomolecules · 年份：2025 · DOI：10.3390/biom15020210 · 被引用次数：39 · 研究领域：Quinazolinone synthesis and applications、Synthesis and Biological Evaluation、Synthesis and biological activity

Quinazolinones, essential quinazoline derivatives, exhibit diverse biological activities with applications in pharmaceuticals and insecticides. Some derivatives have already been developed as commercial drugs. Given the rising cancer incidence, there is a critical need for new anticancer agents, and quinazolinones show promising potential in this domain. The present review focuses on novel advances in the synthesis of these important scaffolds and other medicinal aspects involving drug design, the structure-activity relationship, and action mechanisms of quinazoline and quinazolinone derivatives, to help in the development of new quinazoline and quinazolinone derivatives.