Effectiveness of a personalised self-management intervention for people living with long covid (Listen trial): pragmatic, multicentre, parallel group, randomised controlled trial

作者：Monica Busse, Philip Pallmann, Muhammad Riaz, Claire Potter, Fiona J Leggat, Shaun Harris, Andrea J Longman, Rachel Lowe, Adrian Edwards, A Niroshan Siriwardena, Nick Sevdalis, Jackie McRae, Jessica Fish, Bernadette Sewell, Fiona Jones · 发表于：BMJ Medicine · 年份：2025 · DOI：10.1136/bmjmed-2024-001068 · 被引用次数：11 · 研究领域：Long-Term Effects of COVID-19、Amyotrophic Lateral Sclerosis Research、Intensive Care Unit Cognitive Disorders

Objective: To evaluate the effectiveness of Listen, a self-management support intervention, for people living with long covid who were not in hospital. Design: Pragmatic, multicentre, parallel group, randomised controlled trial. Setting: Twenty four sites in England and Wales. Participants: Identified from long covid clinic waiting lists, word of mouth, and adverts/social media self-referred to the trial, 554 adults with long covid were randomised to receive either the Listen trial intervention or NHS usual care. Interventions: The Listen intervention involved up to six one-to-one personalised sessions with trained healthcare practitioners and an accompanying handbook co-designed by people with lived experience and health professionals. Usual NHS care was variable, ranging from no access, access to mobile applications and resources, and to specialist long covid clinics. Main outcome measures: The primary outcome was the Oxford participation and activities questionnaire (Ox-PAQ) routine activities scale score at three months assessed in the intention-to-treat population. Secondary outcomes included Ox-PAQ emotional wellbeing and social engagement scale scores, the Short Form-12 (SF-12) health survey, the fatigue impact scale, and the generalised self-efficacy scale at three months. The EuroQol five-dimension five-level (EQ-5D-5L) assessed health utility. Serious adverse events were recorded. Results: Between 27 May 2022 and 15 September 2023, 554 people with long covid (mean a...