Photoactivation of the cGAS-STING pathway and pyroptosis by an endoplasmic reticulum-targeting ruthenium( ii ) complex for cancer immunotherapy

作者：Bin-Fa Liang, Shan Jiang, Yun-Shi Zhi, Zhengyin Pan, X. Su, Qin Gong, Zhendan He, Dezhong Yao, Liang He, Chenyang Li · 发表于：Inorganic Chemistry Frontiers · 年份：2025 · DOI：10.1039/d4qi03021d · 被引用次数：12 · 研究领域：interferon and immune responses、Inflammasome and immune disorders、Toxoplasma gondii Research Studies

A cholic acid-modified ruthenium( ii ) (Ru1) photosensitizer was synthesized. Ru1 induced pyroptosis and sequentially engaged the downstream proteins p-TBK1 and p-IRF3 within the STING pathway, thus promoting the elicitation of tumor immune responses.