NSUN2-mediated m 5 C modification drives alternative splicing reprogramming and promotes multidrug resistance in anaplastic thyroid cancer through the NSUN2/SRSF6/UAP1 signaling axis

作者：Xiukun Hou, Qiman Dong, Jie Hao, Min Liu, Junya Ning, Mei Tao, Zhongyu Wang, Fengli Guo, Dongmei Huang, Xianle Shi, Ming Gao, Dapeng Li, Xiangqian Zheng · 发表于：Theranostics · 年份：2025 · DOI：10.7150/thno.104713 · 被引用次数：37 · 研究领域：RNA modifications and cancer、RNA Research and Splicing、RNA and protein synthesis mechanisms

These findings suggest that the NSUN2/SRSF6/UAP1 signaling axis plays a vital role in MDR of ATC and identify NSUN2 as a synergistic target for chemotherapy and targeted therapy in ATC.