Glucose homeostasis controls N-acetyltransferase 10-mediated ac4C modification of HK2 to drive gastric tumorigenesis

作者：Qiang Wang, Mengmeng Li, Chen Chen, Chen Chen, Yao Fu, Jiawen Xu, Jiawen Xu, Chuanjun Shu, Zhangding Wang, Zhangding Wang, Changyu Chen, Changyu Chen, Tao Song, Shouyu Wang · 发表于：Theranostics · 年份：2025 · DOI：10.7150/thno.104310 · 被引用次数：21 · 研究领域：Cancer, Hypoxia, and Metabolism、Amino Acid Enzymes and Metabolism、Pancreatic function and diabetes

Our findings highlight the critical crosstalk between glucose homeostasis and the ac4C epitranscriptome in gastric carcinogenesis. This finding offers a potential strategy of targeting NAT10/HK2 axis for the treatment of GC patients, especially those with highly active glucose metabolism.