Histone lactylation-driven B7-H3 expression promotes tumor immune evasion

作者：Zhibo Ma, Jianming Yang, Wenlong Jia, Le Li, Yixin Li, Junjie Hu, Wei Luo, Ronghui Li, Dawei Ye, Peixiang Lan · 发表于：Theranostics · 年份：2025 · DOI：10.7150/thno.105947 · 被引用次数：84 · 研究领域：Cancer Immunotherapy and Biomarkers、Immune cells in cancer、Peptidase Inhibition and Analysis

This study uncovers a novel mechanism by which lactate modulates the immune microenvironment through the glycolysis pathway and B7-H3 expression, providing new avenues for lactate metabolism-targeted tumor immunotherapy.