YBX1-driven TUBB6 upregulation facilitates ocular angiogenesis via WNT3A-FZD8 pathway

作者：Ye-Ran Zhang, Weiqi Li, Zhonghong Zhang, Ru-Xu Sun, Hong-Jing Zhu, Hui-Ming Qian, Songtao Yuan, Wang Yu-liang · 发表于：Theranostics · 年份：2025 · DOI：10.7150/thno.104573 · 被引用次数：6 · 研究领域：Corneal Surgery and Treatments、Ubiquitin and proteasome pathways、Retinopathy of Prematurity Studies

Collectively, our research shed light on the pivotal function of TUBB6 in maintaining ocular homeostasis and uncovered the YBX1-TUBB6-WNT3A/FZD8 pathway's involvement in sprouting angiogenesis. Targeting TUBB6 and developing its specific inhibitor could pioneer new approaches for treating ocular microvascular diseases.