Abstract TMP7: The Obesity Paradox in Asymptomatic Intracranial Arterial Stenosis: Implications for Stroke Risk and Prognosis

作者：Weizhuang Yuan, Manqiu Ding, Yiyang Liu, Yufan Cao, Huanyu Zhou, Yinxi Zou, Caiyan Liu, Weihai Xu · 发表于：Stroke · 年份：2025 · DOI：10.1161/str.56.suppl_1.tmp7 · 研究领域：Cerebrovascular and Carotid Artery Diseases、Acute Ischemic Stroke Management、Neurological Disease Mechanisms and Treatments

Background and purpose: Intracranial arterial stenosis (ICAS) is an important cause of ischemic stroke and is associated with a poor prognosis. Obesity has been reported to be associated with a more favorable prognosis in patients with coronary heart disease, but its impact on ICAS remains largely unexplored. This study aimed to investigate the association between obesity and prognosis in patients with asymptomatic ICAS. Methods: This retrospective cohort study included ICAS patients without stroke history, all of whom had been assessed with transcranial Doppler indicating more than 50% stenosis. Participants were categorized into four groups based on their body mass index (BMI): underweight (BMI<18.5 kg/m 2 ), normal weight (18.5≤BMI<24 kg/m 2 ), overweight (24≤BMI<28 kg/m 2 ) and obese (BMI≥28 kg/m 2 ). The primary outcomes were the occurrence of ischemic stroke and the functional outcomes, which were assessed using the modified Rankin Score (mRS). A poor prognosis is defined as an mRS>2. The association between BMI and prognosis of asymptomatic ICAS was investigated by multivariable analysis. Results: A total of 1248 asymptomatic ICAS patients were included, distributed as follows: 46 underweight, 516 normal weight, 522 overweight, and 164 obese. With a median follow-up of 48 months, the incidence of ischemic stroke was 8.7%, 6.5%, 5% and 1.2% across the underweight, normal weight, overweight, and obese groups, respectively. The poor prognosis rates were 25.6%,...