Abstract TP274: The Changes in Long-term Disease Burden Associated with the Progression from Asymptomatic to Symptomatic Intracranial Stenosis: A Hospital-Based Cohort Study

作者：Yiyang Liu, Manqiu Ding, Yinxi Zou, Huanyu Zhou, Zongmuyu Zhang, Shun Li, Yinghuan Hu, Yuexuan Dai, Xin Li, Shan Gao, Yuelun Zhang, Caiyan Liu, Yan Xu, Weihai Xu · 发表于：Stroke · 年份：2025 · DOI：10.1161/str.56.suppl_1.tp274 · 研究领域：Cerebrovascular and Carotid Artery Diseases、Acute Ischemic Stroke Management、Neurological Disease Mechanisms and Treatments

Background: Intracranial artery stenosis (ICAS) is a progressive pathological process. No study has focused on changes in long-term disease burden associated with the progression from asymptomatic to symptomatic ICAS stages, which inform future preventive strategies and health management. Methods: We performed an ambispective cohort study that included consecutive patients with 50% or greater ICAS diagnosed by transcranial Doppler from January 2016 to May 2022. All patients received follow-ups through August 2023. The primary outcomes were ischemic stroke, all-cause mortality, and global cognitive decline. Results: Of 1872 eligible patients, 1628 (87.0%) were interviewed (1004 [61.7%] with asymptomatic ICAS; 624 [38.3%] with symptomatic ICAS). The mean age of the patients was 62.4±13.3 years. During a median follow-up of 3.7 years (IQR, 2.4-5.2), 60 (6.0%) patients with asymptomatic ICAS had a first-ever ischemic stroke, 63 (6.3%) died, and 7.6% had self-reported cognitive decline (global Everyday Cognition scale ≥ 2). During a median follow-up of 3.8 years (IQR, 2.2–5.4), 98 (15.7%) patients with symptomatic ICAS had recurrent ischemic stroke, 93 (14.9%) died, and 18.2% had self-reported cognitive decline. The cumulative incidence of ischemic stroke and all-cause mortality by five years were 7.5% (95% CI, 5.4%-9.6%) and 7.7% (95% CI, 5.5%-9.9%) among patients with asymptomatic ICAS, while those in patients with symptomatic ICAS were 18.2% (95% CI, 14.7%-21.8%) and 17.9% (95%...