Effects of Porphyromonas gingivalis Outer Membrane Vesicles ( OMVs ) on Macrophages in Periodontitis

作者：S Zhang, Jiao Yao, Siyan Liu, Yitong Liu, Yi Liu · 发表于：Oral Diseases · 年份：2025 · DOI：10.1111/odi.15264 · 被引用次数：7 · 研究领域：Oral microbiology and periodontitis research、Extracellular vesicles in disease、Bone and Dental Protein Studies

OBJECTIVE: To review the effect of outer membrane vesicles (OMVs) of the periodontal pathogen Porphyromonas gingivalis (P. gingivalis) on macrophages during periodontitis development. METHOD: Literature pertaining to P. gingivalis OMVs and macrophages was reviewed and discussed, with a focus on the immunomodulatory effects of P. gingivalis OMVs on macrophages. RESULTS: P. gingivalis OMVs affect the recognition, phagocytosis, polarization, and apoptosis functions of macrophages. However, information on their antigen-presenting effect remains lacking, and further research is required for clinical applications. CONCLUSION: P. gingivalis OMVs can influence the development of periodontitis through immune modulation of macrophages; however, further research is required to provide novel ideas for the prevention and treatment of periodontitis.