Diverse Annulations of Alkyl(phenyl)phosphinic Chlorides and Imines

作者：Mengyao Zhang, Hongguang Du, Jiaxi Xu · 发表于：Organic Letters · 年份：2025 · DOI：10.1021/acs.orglett.4c04737 · 被引用次数：7 · 研究领域：Synthesis of β-Lactam Compounds、Asymmetric Hydrogenation and Catalysis、Asymmetric Synthesis and Catalysis

The reactivity of alkyl(aryl)phosphinic chlorides and imines was investigated in the presence of a base. The results indicated that allyl/benzyl(aryl)phosphinic chlorides gave rise to 1,2-azaphosphines (δ-phostims), while nonbenzylic alkyl(aryl)phosphinic chlorides produced the corresponding β-phosphinolactams (β-phostims) in their reaction with cyclic dibenzo[ b, f ][1,4]oxazepines, whereas steric electron-rich arylmethyl(aryl)phosphinic chlorides generated [2 + 2 + 2] annuloadducts in some cases. The current investigation provides useful insight into the reactivity of phosphinic chlorides and imines.