SERINC2-mediated serine metabolism promotes cervical cancer progression and drives T cell exhaustion

作者：Yixuan Sun, Yang Zhou, Qihua Peng, Wanzhen Zhou, Xiao Li, Ruiwen Wang, Yifan Yin, Huixian Huang, Hong‐Fei Yao, He Li, Xueli Zhang, Lipeng Hu, Shu‐Heng Jiang, Zhigang Zhang, Dongxue Li, Xiaolu Zhu, Yincheng Teng · 发表于：International Journal of Biological Sciences · 年份：2025 · DOI：10.7150/ijbs.105572 · 被引用次数：16 · 研究领域：Epigenetics and DNA Methylation、RNA modifications and cancer、Bladder and Urothelial Cancer Treatments

T cells and rendered T cell exhaustion. Overall, SERINC2 remodels cancer development and serine metabolism in the tumor immune microenvironment (TIME), establishing an immunosuppressive and pro-tumoral milieu.