USP5 Binds and Stabilizes EphA2 to Increase Nasopharyngeal Carcinoma Radioresistance

作者：Jie-Yu Tang, Yun‐Xi Peng, Wei Zhu, Jie-Ya Qiu, Wei Huang, Yi Hong, Shan-Shan Lu, Juan Feng, Zheng-Zheng Yu, Di Wu, Qi Wen, Yuan Li, Jinwu Peng, Zhi‐Qiang Xiao · 发表于：International Journal of Biological Sciences · 年份：2025 · DOI：10.7150/ijbs.102461 · 被引用次数：5 · 研究领域：Cancer-related gene regulation、Axon Guidance and Neuronal Signaling、Ubiquitin and proteasome pathways

NPC cell radioresistance via targeting USP5/EphA2 axis. Moreover, the levels of USP5 and EphA2 are significantly higher in the radioresistant NPCs than those in the radiosensitive NPCs, and both proteins for predicting patient prognosis are superior to individual protein. These findings suggest that USP5 binds and stabilizes EphA2 by ubiquitin proteasome pathway to promote NPC radioresistance, and MBZ increases NPC radiosensitivity by targeting USP5/EphA2 axis, and is a potential radiosensitizer in NPC and perhaps in other cancers.