Prp19/CDC5L promotes gastric cancer via activation of the MAPK pathway-mediated homologous recombination

作者：Shengkui Qiu, Feiran Wang, Feiran Wang, Xuesong Gao, Weiyu Guan, Ting Dai, Lei Yin, Fei Wang, Fei Wang, Jinjie Sun, Peng Guo, Hao Wu, Shichun Feng, Chong Tang · 发表于：International Journal of Biological Sciences · 年份：2025 · DOI：10.7150/ijbs.101962 · 被引用次数：4 · 研究领域：CRISPR and Genetic Engineering

In summary, our study confirms that Prp19 upregulates CDC5L expression, which binds to MAPK1, thereby promoting GC progression via the MAPK pathway-mediated homologous recombination. Targeting CDC5L could be a promising strategy in the precision therapy of GC.