Mental Health Disparities by Sexual Orientation and Gender Identity in the All of Us Research Program

作者：Junjie Lu, Shamsi Soltani, S. Bryn Austin, David H. Rehkopf, Mitchell R. Lunn, Marvin E. Langston · 发表于：JAMA Network Open · 年份：2025 · DOI：10.1001/jamanetworkopen.2024.56264 · 被引用次数：30 · 研究领域：LGBTQ Health, Identity, and Policy、HIV/AIDS Research and Interventions、African Sexualities and LGBTQ+ Issues

Importance: Limited research explores mental health disparities between individuals in sexual and gender minority (SGM) populations and cisgender heterosexual (non-SGM) populations using national-level data. Objective: To explore mental health disparities between SGM and non-SGM populations across sexual orientation, sex assigned at birth, and gender identity within the All of Us Research Program. Design, Setting, and Participants: This cross-sectional study used survey data and linked electronic health records of eligible All of Us Research Program participants from May 31, 2017, to June 30, 2022. Exposure: Self-identified SGM status. Main Outcomes and Measures: Prevalence of common mental health conditions identified from linked electronic health records. Logistic regression adjusted for age, race and ethnicity, educational level, income, employment status, and geographic region was used to assess the association between SGM status and mental health conditions. Results: Among 413 457 participants, 269 947 (65.3%) were included in the analysis (median age, 59 [IQR, 43-70] years), with 22 189 (8.2%) self-identified as SGM. Men with cisgender sexual minority identity had higher odds of bipolar disorder (adjusted odds ratio [AOR], 1.87; 95% CI, 1.70-2.56) compared with cisgender heterosexual men. Women with cisgender sexual minority identity had higher odds of bipolar disorder (AOR, 2.09; 95% CI, 1.95-2.25) compared with cisgender heterosexual women. Gender diverse people assig...