508. Cabotegravir Long-Acting for Pre-Exposure Prophylaxis (PrEP): Real World Data on On-Time Dosing, HIV Testing and HIV Acquisition from the OPERA Cohort

作者：Anthony Mills, Laurence Brunet, Kevin R. Frost, Ricky Hsu, Gerald Pierone, Michael Sension, Philip Lackey, Karam Mounzer, Michael Wohlfeiler, Jennifer S Fusco, Carolyn Brown, Vani Vannappagari, Michael Aboud, Piotr Budnik, Gregory Fusco · 发表于：Open Forum Infectious Diseases · 年份：2025 · DOI：10.1093/ofid/ofae631.160 · 被引用次数：3 · 研究领域：HIV/AIDS drug development and treatment、HIV-related health complications and treatments、HIV Research and Treatment

Abstract Background Cabotegravir long-acting (CAB LA) pre-exposure prophylaxis (PrEP) consists of 2 initiation injections given 1 month apart, followed by a continuation injection every 2 months, with HIV testing before each injection. We compared characteristics of CAB LA and oral PrEP users and described patterns of CAB LA dosing and HIV testing. Methods All individuals ≥12 years old with a new oral PrEP or ≥1 CAB LA injection from 21Dec2021-30Jun2023 in the OPERA cohort were included. CAB LA initiation was completed if the first 2 initiation injections were received ≤60 days apart. Patterns of injections were described in complete initiators as on-time (1 month after the first or 2 months after subsequent injections, ±7 days), delayed ( >7 days after the target), requiring re-initiation per label (≥91 days without injection), or ≥2 injection targets missed (≥128 days without injection). HIV testing ≤1 week before/at each injection and cases of HIV acquisition were described. Results The 770 CAB LA users were more likely to be women, on Medicaid, and have a longer history of care at the clinic than the 18603 new oral PrEP users (Table 1). Of 119 (16%) incomplete initiators, 56% received ≥1 additional injection (Table 2). Most complete initiators received all injections on-time (68%). Of the 206 complete initiators with any delayed injections, 50% received their injection ≤1 week late. A third went ≥91 days and 20% went ≥128 days without an injection (Table 3). Only 6...