Spontaneously Photocatalytic Nanoplatform for Sensitive Diagnosis and Penetrated Therapy of Cancer

作者：Huairong Zhang, Feng Lu, Yuqi Wang, Zhiru Bi, Zizhen Wei, Yongbiao Sun, Minghui Shi, Tingting Chen, Linjing Wang, Shusheng Zhang · 发表于：Analytical Chemistry · 年份：2025 · DOI：10.1021/acs.analchem.4c05185 · 被引用次数：8 · 研究领域：Advanced Photocatalysis Techniques、Nanoplatforms for cancer theranostics、Advanced Nanomaterials in Catalysis

In this study, a sensitive diagnosis and spontaneously photocatalytic therapy of cancer based on chemiluminescence (CL) and nanozyme was studied. Briefly, carbon nitride-supported copper nanoparticles (CuCNs) loaded with luminol (CuCN-L) were utilized to develop a microneedle patch (CuCN-L/MN). The CuCN-L probe could target overexpressed H 2 O 2 in the TME and actively emit CL to achieve cancer cell imaging for diagnosis. In addition, 425 nm blue-violet CL could photocatalyze CuCN to reduce carbon dioxide (CO 2 ) to carbon monoxide (CO) for gas therapy (GT). Meanwhile, CuCN, acting as a photosensitizer (PS), could be activated by CL to produce reactive oxygen species (ROS), which realized photodynamic therapy (PDT). Furthermore, the use of a degradable MN based on hyaluronic acid (HA) promotes painless local administration as well as deep administration of GT and PDT. This technology of optical sensor-mediated anticancer treatment will have great potential to provide new inspirations for cancer diagnosis and therapy based on a self-excited nanoplatform.