Health-related quality of life associated with fatigue, physical activity and activity pacing in adults with chronic conditions

作者：Ioulia Barakou, Bregje L. Seves, Ulric Sena Abonie, Tracy Finch, Katie L. Hackett, Florentina J. Hettinga · 发表于：BMC Sports Science Medicine and Rehabilitation · 年份：2025 · DOI：10.1186/s13102-025-01057-x · 被引用次数：17 · 研究领域：Chronic Obstructive Pulmonary Disease (COPD) Research、Balance, Gait, and Falls Prevention、Physical Activity and Health

BACKGROUND: Fatigue and inactivity are linked to decreased health-related quality of life (HRQoL) in chronic conditions. A multidimensional approach to activity pacing may improve HRQoL by promoting physical activity (PA) and alleviating fatigue. Addressing fatigue across chronic conditions is crucial, especially when underlying causes are unknown. This study aimed to (1) examine associations between HRQoL, fatigue, pacing, risk of overactivity, PA, and self-regulation of PA in adults with chronic conditions and (2) examine if these associations differ across HRQoL domains: physical, social, emotional, and functional well-being. METHODS: Sixty-six adults with chronic conditions were recruited from UK fatigue clinics and the community. HRQoL, pacing, risk of overactivity, PA, and self-regulation of PA were assessed with standardised questionnaires and Actigraph monitor. Associations were analysed with linear mixed models, correcting for confounders. RESULTS: HRQoL was significantly associated with fatigue (B=-7.82), pacing (B=-0.23), and self-regulation of PA (B = 0.11). Interaction effects revealed fatigue's impact on HRQoL varied significantly in physical (β=-13.49), social (β=-6.81), and emotional (β=-4.10) domains. Pacing showed significant differences in physical (β=-0.49), social (β=-7.12), and emotional (β=-7.45) domains. Perceived overactivity differed in social domain (β=-6.27), while device-based PA differed in physical (β = 0.35) and social (β = 5.73). CONCLUSION: T...