Seeding Janus Zn–Fe Diatomic Pairs on a Hollow Nanobox for Potent Catalytic Therapy

作者：Jin Ye, Yunlong Li, Jiating Xu, Chunsheng Li, Jiawei Qu, Juan Wang, Yuan‐Hang Chang, Lu Yong, Zhengmin Cai, Chen Wang, Xinqiang Liang, Chaorong Li, Jun Cao, Yujie Fu, Piaoping Yang · 发表于：Nano Letters · 年份：2025 · DOI：10.1021/acs.nanolett.4c05517 · 被引用次数：4 · 研究领域：Advanced Nanomaterials in Catalysis、Gold and Silver Nanoparticles Synthesis and Applications、Innovative Microfluidic and Catalytic Techniques Innovation

Dual atomic nanozymes (DAzymes) are promising for applications in the field of tumor catalytic therapy. Here, integrating with ultrasmall Fe 5 C 2 nanoclusters, asymmetric coordination featuring Janus Zn–Fe dual-atom sites with an O 2 N 2 –Fe–Zn–N 4 moiety embedded in a carbon vacancy-engineered hollow nanobox (Janus ZnFe DAs-Fe 5 C 2 ) was elaborately developed. Theoretical calculation revealed that the synergistic effects of Zn centers acting as both adsorption and active sites, oxygen-heteroatom doping, carbon vacancy, and Fe 5 C 2 nanoclusters jointly downshifted the d-band center of Fe 3d orbitals, optimizing the desorption behaviors of intermediates *OH, thereby significantly promoting catalytic activity. Upon 1064 nm laser irradiation, Janus ZnFe DAs-Fe 5 C 2 with superior photothermal conversion efficiency (η = 62.5%) showed thermal-augmented catalytic therapy. Fascinatingly, Janus ZnFe DAs-Fe 5 C 2 with multienzymatic properties can suppress the expression of glutathione peroxidase 4 and accelerate the accumulation of lipid peroxides, through which ferroptosis is triggered. Overall, tannin-involved asymmetric Janus ZnFe DAs-Fe 5 C 2 will inspire more inventions of biodegradable DAzymes for tumor therapy application.