Cognitive impairments in first-episode psychosis patients with attenuated niacin response

作者：MingLiang Ju, Bin Long, YanYan Wei, XiaoChen Tang, Lihua Xu, RanPiao Gan, HuiRu Cui, Yingying Tang, Zhenghui Yi, HaiChun Liu, HaiChun Liu, Zixuan Wang, Tao Chen, Jin Gao, Qiang Hu, Lingyun Zeng, Chunbo Li, Jijun Wang, HuanZhong Liu, HuanZhong Liu, Tianhong Zhang · 发表于：Schizophrenia Research Cognition · 年份：2025 · DOI：10.1016/j.scog.2025.100346 · 被引用次数：4 · 研究领域：Schizophrenia research and treatment、Tryptophan and brain disorders、Alcoholism and Thiamine Deficiency

Background: Psychosis is a complex brain disorder with diverse biological subtypes influenced by various pathogenic mechanisms, which can affect treatment efficacy. The ANR(Attenuated Niacin Response) subtype is characterized by pronounced negative symptoms and functional impairments, suggesting a distinct clinical profile. However, research on the cognitive characteristics associated with the ANR subtype in drug-naïve first-episode psychosis(FEP) patients remains limited. Methods: This observational study involved 54 FEP patients and 52 healthy controls(HC). Clinical psychopathology was assessed using the Positive and Negative Syndrome Scale(PANSS), while cognitive performance was evaluated through the Chinese version of the MATRICS Consensus Cognitive Battery(MCCB). Additionally, niacin response was measured using aqueous methylnicotinate patches, with responses quantified to classify participants into ANR or normal niacin response (NNR) groups. Results: = 0.012). The ANR group exhibited more severe negative symptoms and higher total PANSS scores compared to the NNR group, with significant differences in cognitive performance on the Trail Making test and the Brief Visuospatial Memory Test-Revised. Correlation analyses revealed a significant positive relationship between overall symptom severity and niacin response, as well as between cognitive performance and niacin response, particularly for the Trail Making and Symbol coding tests. Conclusions: This study demonstrates tha...