Efficacy and safety of a modified DVD regimen followed by lenalidomide for the treatment of Newly Diagnosed Multiple Myeloma

作者：Zhichao Li, Wenhao Zhang, Fang Huang, Siguo Hao · 发表于：Clinics · 年份：2025 · DOI：10.1016/j.clinsp.2025.100575 · 被引用次数：1 · 研究领域：Multiple Myeloma Research and Treatments、Protein Degradation and Inhibitors、Acute Myeloid Leukemia Research

• Adverse effects of lenalidomide for Newly Diagnosed Multiple Myeloma (NDMM) cannot be ignored. • Lower-dose PLD administered with dexamethasone and subcutaneous bortezomib is associated with a good durable response. • Lenalidomide is retained as maintenance or salvage therapy if the DVD regimen fails. The common drugs used for the treatment of Newly Diagnosed Multiple Myeloma (NDMM) include bortezomib and lenalidomide, but the adverse effects of lenalidomide cannot be ignored, especially when it is used in the initial therapy. This retrospective study evaluated the efficacy and safety of a modified DVD regimen (pegylated liposomal doxorubicin, bortezomib, and dexamethasone) followed by lenalidomide in the treatment of NDMM. A total of 40 NDMM patients were treated with a reduced dose of pegylated liposomal doxorubicin (20 mg/m 2 ) on day 1, subcutaneous bortezomib (1.3 mg/m 2 ) on days 1, 4, 8, and 11, and dexamethasone (20 mg) on days 1, 2, 3, 4, 8, 9, 11, and 12 (20 days for each course). When patients failed to achieve partial or better response after 2 courses of treatment, a regimen containing lenalidomide was administered. After the induction therapy, 15 eligible patients received Peripheral Blood Stem Cells (PBSC) mobilization and transplantation followed by maintenance therapy with lenalidomide. The response rate (≥ very good partial response) was 55% and 80% after 2 and 4 courses, respectively. The 18-month Progression Free Survival (PFS) and Overall Survival (OS) ...