Design, synthesis and structure-activity relationship of novel 1,2,4-triazolopyrimidin-5-one derivatives targeting GABAA1 and Nav1.2 with antiepileptic activity

作者：Tongtong Du, Jun Wu, Weina Wang, Wenhui Liang, Yunjie Li, Chuanlong Guo, Xiufen Li, Longjiang Huang, Haibo Yu · 发表于：European Journal of Medicinal Chemistry · 年份：2025 · DOI：10.1016/j.ejmech.2025.117316 · 被引用次数：11 · 研究领域：Phenothiazines and Benzothiazines Synthesis and Activities、Chemical Synthesis and Analysis、Synthesis and Reactivity of Heterocycles