Correlation between atherogenic index of plasma and cardiovascular disease risk across Cardiovascular–kidney–metabolic syndrome stages 0–3: a nationwide prospective cohort study

作者：Yaohua Hu, Liang Yu, Jiandong Li, Xinyang Li, Mengyuan Yu, Wenpeng Cui · 发表于：Cardiovascular Diabetology · 年份：2025 · DOI：10.1186/s12933-025-02593-z · 被引用次数：57 · 研究领域：Chronic Kidney Disease and Diabetes、Diabetes, Cardiovascular Risks, and Lipoproteins、Birth, Development, and Health

BACKGROUND: The Cardiovascular-kidney-metabolic (CKM) syndrome, a concept recently proposed by the American Heart Association (AHA), highlights the intricate connection between metabolic, renal, and cardiovascular illnesses. Furthermore, the Atherogenic Index of Plasma (AIP), a useful biomarker for evaluating the risk of Cardiovascular Diseases (CVDs), has been associated with the risk of Adverse Cardiovascular Events (ACEs). Nonetheless, its precise function in populations in CKM syndrome Stages 0-3 remains unknown. METHODS: This prospective study analyzed the data of 7,708 eligible participants (aged ≥ 45 years) from the Chinese Longitudinal Research of Ageing (CHARLS), particularly the 2011-2012 baseline survey (Wave 1). The primary exposure variable was AIP-a natural logarithm of the ratio of Triglycerides (TGs) to High-Density Lipoprotein Cholesterol (HDL-C). On the other hand, the primary endpoint was CVD incidence, which was determined based on self-reported past diagnoses. The relationship between AIP and CVD risk in the population in CKM syndrome stages 0-3 was examined using a Cox proportional risk model. Subgroup and mediation analyses were performed to further elucidate the interactions among these factors. RESULTS: This study involved 7,708 participants in the CKM syndrome stages 0-3 [Mean age = 58.00 years; Interquartile Range (IQR) = 52.00-65.00 years]. The risk of developing CVD increased significantly with higher AIP levels. Specifically, the risk ratio for e...